Vitamin d 3 is made in the skin and modified in the liver and kidney to form the active metabolite 125 dihydroxyvitamin d 3 calcitriol calcitriol binds to a nuclear receptor the vitamin d receptor vdr and activates vdr to recruit cofactors to form a transcriptional complex that binds to vitamin d response elements in the promoter region of target genes. Vitamin d receptor agonists kidney diseases by theodoros eleftheriadis 9781616688608 available at book depository with free delivery worldwide. And applications in chronic kidney disease the vitamin d receptor agonist salt analyzed the genetic basis for common renal diseases including ckd and related factors such as . Vitamin d has been recently associated with several renal cardiovascular and inflammatory diseases beyond mineral metabolism and bone health this is due in part to widespread expression of vitamin d receptor vdr on tissues and cells such as heart kidney immune cells brain and muscle. Vascular calcification in chronic kidney disease ckd is induced via both passive ca x p deposition and active transformation of vascular smooth muscle cells vsmcs into an osteoblast like phenotype the vitamin d receptor vdr agonist paricalcitol is very useful in the treatment of ckd patients
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